发明名称 |
SECRETED ACID PHOSPHATASE (SAPM) IS PRESENT ONLY IN PATHOGENIC MYCOBACTERIA AND EXPRESSED SELECTIVELY AT ACIDIC PH |
摘要 |
The invention relates to an isolated DNA construct, comprising a mycobacterium secreted acid phosphatase promoter or promoter fragment which is inducible by low pH. This invention further relates to diagnostic methods and vaccines for treatment or prophylaxis of pathogenic mycobacterial disease or infection. This invention also provides for methods of screening for compounds capable of modulating the activity, production or secretion of a mycobacterium secreted acid phosphatase. |
申请公布号 |
WO2004033677(A3) |
申请公布日期 |
2004.06.17 |
申请号 |
WO2003CA01554 |
申请日期 |
2003.10.09 |
申请人 |
LIU, JUN;SALEH, MAZEN, T.;ALEXANDER, DAVID |
发明人 |
LIU, JUN;SALEH, MAZEN, T.;ALEXANDER, DAVID |
分类号 |
A61K38/00;A61K39/00;A61K39/04;C07K16/12;C12N9/16;C12N15/52;C12N15/55;C12N15/57;C12N15/63;G01N33/50 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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