| 摘要 |
Compounds which are active against viruses have the following formulas: Formula (I), Formula (II), wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine) , 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purine s such as 2-amino~6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6- alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6- cyclopropylaminopurine, 2-amino-~6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-~6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives wit h a saturated or unsaturated alkyl group and 6-azapyrimidines.
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