| 摘要 |
The preparation of cyclic-sulfur fluorine containing oxazolidinone antibacterial agents by reaction of the 4-bromo-3-fluorinated carbamate with tetrahydrothiopyran-4-one to produce a tetrahydrothiopyran-o-fluorinated compound (IV), where Rester is selected from the group consisting of: (I) C1-C10 alkyl optionally substituted with: (A) phenyl, (B) 1 to 3 C1-C3 alkoxy, (II) C2-C5 alkenyl optionally substituted with: (A) phenyl, (B) C3-C7 cycloalkyl, (III) phenyl optionally substituted with one to three C1-C3 alkyl (IV) naphthyl optionally substituted with one to three C1-C3 alkyl The tetrahydrothiopyran-o-fluorinated compound (IV) is a key intermediate to making oxazolidinone antibacterial agents which contain the tetrahydrothiopyran-o-fluorinated group.
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