Compounds and methods for the identification and/ or validation of a target

摘要

The present invention is related to a compound, preferably 14 to 30 nucleobases, preferably 17 to 23 nucleobases and more preferably 17 to 21 nucleobases in length, targeted to a nucleic acid whereby the nucleic acid is heterogeneous nuclear RNA (hnRNA). The present invention is also related to a method for the identification and/or validation of a target wherein the target is part of a tumor suppressor related pathway comprising the following step: a) applying to an expression system a functional oligonucleotide wherein the functional oligonucleotide is specific for an mRNA encoding the tumor suppressor.