| 发明名称 |
CHEMOKINE MUTANTS ACTING AS CHEMOKINE ANTAGONISTS |
| 摘要 |
Mutants of specific CC-chemokines containing a non-conservative substitution in a conserved consensus sequence act as CC-chemokine antagonists, and can b e effectively used in the treatment of autoimmune and inflammatory diseases, cancers, and viral or bacterial infections. Particularly preferred are the RANTES/CCL5 mutants having the amino acid sequence of SEQ ID NO: 1, 2 , 3, o r 4.
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| 申请公布号 |
CA2468790(A1) |
申请公布日期 |
2003.06.26 |
| 申请号 |
CA20022468790 |
申请日期 |
2002.12.16 |
| 申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
PROUDFOOT, AMANDA;SHAW, JEFFREY;KOSCO-VILBOIS, MARIE |
| 分类号 |
C12N15/09;A61K38/00;A61K38/19;A61K45/00;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P37/06;C07K14/47;C07K14/52;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/19;C12P21/02;(IPC1-7):C12N15/19;A61P37/00;C12N15/63 |
主分类号 |
C12N15/09 |
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