摘要 |
<p>The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilising microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.</p> |
申请人 |
ALPHARMA AS;GARDNER, REBECCA;SVENDSEN, JOHN, SIGURD;HAUG, BENGT, ERIK;MARKO, ISTVAN;REKDAL, OEYSTEIN;SKAR, MERETE, LINCHAUSEN;STENSEN, WENCHE;STROEM, MORTEN, BOEHMER |
发明人 |
SVENDSEN, JOHN, SIGURD;HAUG, BENGT, ERIK;MARKO, ISTVAN;REKDAL, OEYSTEIN;SKAR, MERETE, LINCHAUSEN;STENSEN, WENCHE;STROEM, MORTEN, BOEHMER |