发明名称 |
Radioprotectant for peptides labeled with radioisotope |
摘要 |
A method of ameliorating degradation radiolabeled peptides, especially radiolabeled proteins such as antibodies, by including povidone, also widely known as polyvinylpyrrolidone or PVP, as a radioprotectant in a composition containing a radiolabeled peptide is described. A radioprotectant composition and a stable peptide-radioisotope composition having povidone are also described. Ascorbic acid or other secondary stabilizers may also be added to the compositions to further enhance radioprotection. |
申请公布号 |
US6338835(B1) |
申请公布日期 |
2002.01.15 |
申请号 |
US19990453985 |
申请日期 |
1999.12.02 |
申请人 |
COULTER PHARMACEUTICAL, INC. |
发明人 |
SHOCHAT DAN;CHAN ALBERT S. K.;BUCKLEY MICHAEL J.;COLCHER DAVID |
分类号 |
A61K51/00;A61K39/395;A61K51/08;A61K51/12;A61P37/00;(IPC1-7):A61K51/00;A61M36/14 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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