摘要 |
The present invention relates to a compound having the general formula (I) where the dashed line indicates that formula (I) is optionally cyclic, and the bonds shown represent covalent bonds; and wherein A represents a chemical moiety having an amino group (radical) and a carboxy group that forms part of the peptide bond connecting A to X and B; B represents a chemical moiety having an amino group (radical) and a carboxy group that forms part of the peptide bond connecting B to A and Y; X represents a peptide sequence of from 1 to 3 amino acid residues which independently may be an L or D form when Y represents a C-terminal peptide sequence of from 2 to 5 amino acid residues which may independently be L- or D-forms; or X represents an N-terminal modification of the group A-B when Y represents a C-terminal peptide sequence of from 2 to 5 amino acid residues which may independently be L- or D-forms; or X represents a peptide sequence of from 2 to 5 amino acid residues which may independently be L- or D-forms when Y represents a C-terminal peptide sequence of from 1 to 3 amino acid residues which independently may be an L or D form; and when formula (I) represents a linear peptide X is optionally chemically modified at its N-terminal, and L is an optional linking group comprising from 0 to 8 backbone atoms; and a mirror image or a retro analogue of formula (I), or a derivative of formula (I) which is a pharmaceutically acceptable salt, and alkyl, aryl or aralkyl ester, an amide, a mono or disubstituted amide where the substituent is an alkyl, an aryl or an aralkyl, a hydrazide, or an alcohol.
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申请人 |
ZEALAND PHARMACEUTICALS A/S;LARSEN, BJARNE, DUE;PETERSEN, JOERGEN, SOEBERG;MEIER, EDDI;KJOELBYE, ANNE, LOUISE;JOERGENSEN, NIKLAS, RYE;NIELSEN, MORTEN, SCHAK;HOLSTEIN-RATHLOU, NIELS-HENRIK;MARTINS, JAMES, B. |
发明人 |
LARSEN, BJARNE, DUE;PETERSEN, JOERGEN, SOEBERG;MEIER, EDDI;KJOELBYE, ANNE, LOUISE;JOERGENSEN, NIKLAS, RYE;NIELSEN, MORTEN, SCHAK;HOLSTEIN-RATHLOU, NIELS-HENRIK;MARTINS, JAMES, B. |