| 摘要 |
PURPOSE: Provided are 1,2,4,5-tetrahydro-benzo£D|azepine derivatives which are antagonists at metabotropic glutamate receptors, as well as with their pharmaceutically acceptable salts in their racemic and optically active form and pharmaceutically acceptable excipients. CONSTITUTION: The compound is represented by the formula(1) defined as in the description. A medicament comprising it is useful for the control or prevention of acute and/or chronic neurological disorders such as epilepsy, stroke, chronic and acute pain psychosis, schizophrenia, Alzheimer's disease cognitive disorders, memory deficits, restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, Huntington's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate deficiency functions, such as e.g. muscle spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, dyskinesia and depression.
|
