| 摘要 |
<p>The present invention provides a method for attenuating acute onset of heart rate or blood pressure increase in patients where the use of nitrate-containing drugs is contraindicated. Specifically disclosed are a method and a combination therapy for the control of heart rate or blood pressure during short term activities following administration of drugs such as sildenafil for treatment of impotence. The method comprises administration of beta-blockers, preferably rapid-acting beta blockers, such as (S)-(-)-ethyl 3-[2-[2-hydroxy-3-(isopropylamino) propoxy]phenyl]propionate hydrochloride at the onset of symptoms, at a pre-determined time before or following administration of sildenafil, or concomitantly with sildenafil or similar-acting anti-impotence agents.</p> |
