摘要 |
PURPOSE: N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides, formulations thereof and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. CONSTITUTION: A sulfonamide compound of formula (A) or a pharmaceutically acceptable salt, acid or ester thereof, are provided, wherein: Ar1 is a substituted with one or more substituents or an unsubstituted monocyclic or polycyclic aryl or heteroaryl group in whcih the each substituent is independently selected from the group consisting of H, NH2, halide, pseudohalide, alkyl, alkylcarbonyl, formyl, aryl, heteroaryl, alkoxyalkyl, alkylamino, alkylthio, arylcarbonyl, aryloxy, arylamino, arylthio, haloalkyl, haloaryl, and carbonyl, in which the aryl and alkyl portions are unsubstituted or substituted with any of the preceeding groups, and straight or branched chains of from about 1 up to about 12 carbons; Ar2 has the following formulae.
|