发明名称 |
Methods and kits for making polypeptides having a single covalently bound N-terminal water-soluble polymer |
摘要 |
This invention provides compositions consisting essentially of a polypeptide and a water-soluble polymer covalently bound thereto at the N-terminal alpha -carbon atom via a hydrazone or reduced hydrazone bond, or an oxime or reduced oxime bond. This invention also provides methods of making the instant compositions, pharmaceutical compositions comprising same, and kits for use in preparing same.
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申请公布号 |
US6077939(A) |
申请公布日期 |
2000.06.20 |
申请号 |
US19970905310 |
申请日期 |
1997.08.01 |
申请人 |
ORTHO-MCNEIL PHARMACEUTICAL, INC. |
发明人 |
WEI, ZIPING;MENON-RUDOLPH, SUNITHA;GHOSH-DASTIDAR, PRADIP |
分类号 |
A61K38/00;A61K47/48;C07K1/107;C07K14/505;C07K17/02;C08G65/32;C12N11/00;(IPC1-7):C07K1/00;A01N37/18 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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