发明名称 WATER-SOLUBLE PHARMACEUTICAL COMPOSITION IN AN IONIC COMPLEXAND THE USE THEREOF
摘要 A water-soluble composition containing a complex of an ionic pharmaceutically effective polypeptide selected from the group consisting of hedgehog proteins, bone morphogenetic proteins, growth factors, erythropoietin, thrombopoietin, G-CSF, interleukins and interferons, characterized in that said composition contains, in addition, an amphiphilic compound, said polypeptide and said amphiphilic compound forming an ionic complex, whereby the forming of the complex does not enhance the solubility of said polypeptide, is suitable for increasing the activity of the polypeptide and/or for the delayed release of the polypeptide.
申请公布号 CA2281049(A1) 申请公布日期 2000.03.01
申请号 CA19992281049 申请日期 1999.08.30
申请人 F. HOFFMANN-LA ROCHE AG 发明人 PAPADIMITRIOU, APOLLON
分类号 A61K38/00;A61K;A61K9/00;A61K9/08;A61K9/107;A61K38/02;A61K38/04;A61K38/16;A61K38/17;A61K38/18;A61K38/20;A61K38/21;A61K38/22;A61K38/36;A61K45/00;A61K47/12;A61K47/28;A61K47/48;A61P43/00;C07K7/00;(IPC1-7):A61K38/17 主分类号 A61K38/00
代理机构 代理人
主权项
地址