Indole derivatives as 5-HT receptor antagonist

摘要

PCT No. PCT/EP96/00368 Sec. 371 Date Oct. 16, 1997 Sec. 102(e) Date Oct. 16, 1997 PCT Filed Jan. 26, 1996 PCT Pub. No. WO96/23783 PCT Pub. Date Aug. 8, 1996A compound of formula (I) or a salt thereof: wherein: P1 is pyridyl; P2 is phenyl; A is a bond or a chain of 1 to 5 atoms optionally substituted by C1-6alkyl; R1 and R2 groups are each independently hydrogen, C1-6alkyl optionally substituted by NR12R13, C2-6alkenyl, C2-6alkynyl, cyano, halogen, CF3, NR12R13, CHO, OCF3, COR14, CH2OR14 or OR14 where R12, R13 and R14 are independently hydrogen or C1-6alkyl; n and m are independently 0, 1 or 2; R3 is hydrogen or C1-6 alkyl; R4 is a group of formula (i): in which: R6 and R7 are independently hydrogen, C1-6 alkyl optionally substituted by one or more fluorine atoms, C1-6alkylthio, C1-6alkoxy or halogen.