| 摘要 |
PROBLEM TO BE SOLVED: To produce trehalose useful as a preservative for pharmaceuticals, physiologically active substances, foods, etc., a water-retaining agent for cosmetics, etc., in a high efficiency by treating sucrose e.g. with a microorganism capable of producing an enzyme for converting sucrose into trehalose. SOLUTION: The trehalose useful as a preservative for useful substances such as pharmaceuticals, diagnostics, hormones, fertilized eggs, sperms, physiologically active substances, enzymes and microorganisms and for foods, etc., a water-retaining agent for cosmetics, etc., is produced in large quantities at a low cost by treating sucrose with a microorganism capable of producing an enzyme for converting sucrose into trehalose [e.g. Corynebacterium sp. FS637 (FERM P-16384) and Arthrobacter sp. FK13 (FERM P-16383)], its cell or treated cell in the presence of a heavy metal ion such as Ni<2+> , Co<2+> or Sn<2+> independent of inorganic phosphoric acid and/or phosphoric acid salt, thereby converting sucrose into trehalose. |
