| 摘要 |
A method is described for estimating the bone quality of a vertebrate, on the basis of two-dimensional image data comprising information relating to the trabecular structure of at least a part of a bone of the vertebrate, the image data being data obtained by exposing at least the part of the bone to electromagnetic radiation, the method comprising subjecting the image data to a statistical analysis comprising a background correction procedure in which low frequent intensity variations not related to the trabecular structure of the bone is reduced relative to image data related to the trabecular structure of the part of the bone, an image manipulation and feature extraction procedure wherein at least the local image intensity information as well as variation in the local intensity are utilized to extract information related to the trabecular structure of the part of the bone, the image manipulation and feature extraction procedure comprising subjecting the image data to at least one of the following procedures: (a) obtaining an estimate of the parametric estimate of the power spectrum of the image data and extracting features relating to the energy distribution of the parametric estimate, (b) obtaining, on the basis of image data on which a Fourier method has been used to emphasize the information in the image data relating to the trabecular structure, an estimate of a grey-level co-occurrence matrix and extracting at least one feature on the basis of the estimated co-occurrence matrix, (c) obtaining an estimate of the projected trabecular pattern of the image data by using a Fourier method to emphasize the information in the image data relating to the trabecular structure and subjecting the manipulated image data to a morphological operation, and extracting features relating to the trabecular structure from the estimated projected trabecular pattern, (d) obtaining, on the basis of a frequency analysis of the image data, features relating to the periodicity of the trabecular structure of the part of the bone, and an estimation procedure in which the bone quality of the vertebrate is estimated on the basis of the derived features and optionally other features related to the bone or the vertebrate and a predetermined relationship between the features and reference bone quality parameters. The present method may provide multiple R-squared values higher than 0.8 on data derived from typical X-ray images of selected bones when determining the optimal fracture strength of the bone. <IMAGE>
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