| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new nucleic acid, containing a polyether skeleton carrying a plurality of ligands individually bound to a chiral carbon atom in the skeleton such as a natural nucleobase, its binding group and a DNA inserting factor and useful as a pseudonucleotide, etc., useful in biochemistry and medicine. SOLUTION: This new polyether nucleic acid comprises a polyether skeleton, having the formula [(n) is an integer of >1; B1 to Bn are each a chemical functional group and at least one of B1 to Bn is a natural nucleobase, a nucleobase binding group or a DNA inserting factor; Y1 to Yn are each the first linker group; X1 to Xn are each the second linker group; C1 to Cn are each a chiral carbon atom; K and I are each the first and the second exoconjugant] and carrying a plurality of ligands individually bound to the chiral carbon atom located in the skeleton and at least one of the ligands contains components such as the natural nucleobase, nucleobase binding group and DNA inserting factor. The polyether nucleic acid is useful as an antisense oligonucleotide analog, etc., capable of controlling the gene expression in the fields of biochemistry and medicine.
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