发明名称 |
Argine antagonists for inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
摘要 |
A method for prophylaxis or treatment of an animal for systemic hypotension induced by internal nitrogen oxide production. The method involves administering a therapeutically effective amount of certain arginine derivatives to inhibit nitrogen oxide formation from arginine. Preferably NG-substituted arginine or an NG,NG-disubstituted arginine (having at least one hydrogen on a terminal guanidino amino group replaced by another atomic species) is administered to an animal possibly developing or already having such induced systemic hypotension. The arginine derivatives are preferably of the L configuration and include pharmaceutically acceptable addition salts. Prophylaxis or treatment of systemic hypotension in a patient which has been induced by chemotherapeutic treatment with biologic response modifiers such as tumor necrosis factor or interleukin-2 may be accomplished. Treatment of an animal for systemic hypotension induced by endotoxin, i.e., septic shock may also be accomplished by treatment with the arginine derivatives.
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申请公布号 |
US5770623(A) |
申请公布日期 |
1998.06.23 |
申请号 |
US19950561717 |
申请日期 |
1995.11.22 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
KILBOURN, ROBERT G.;GROSS, STEVEN S.;LEVI, ROBERTO;GRIFFITH, OWEN W. |
分类号 |
A61K31/195;A61K31/198;A61K31/223;A61K31/44;(IPC1-7):A61K31/195 |
主分类号 |
A61K31/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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