发明名称 |
A method of preparing the enantiomers of o-demethyltramadol |
摘要 |
Preparation of the enantiomers of O-demethyltramadol (II) comprises: (a) converting racemic tramadol (I) salt to its base form; (b) separating the (-)-(I)-enantiomer by precipitation using L-(+)-tartaric acid; (d) reaction of the (-)-(I)-enantiomer with diisobutyl aluminium hydride (DIBAL) to give (-)-(II); (e) separation of the (+)-(I)-enantiomer as a free base from the mother liquor obtained in step (b); and (f) reaction of the (+)-(I) enantiomer with DIBAL to give (+)-(II). |
申请公布号 |
ZA9700367(B) |
申请公布日期 |
1997.07.17 |
申请号 |
ZA19970000367 |
申请日期 |
1997.01.16 |
申请人 |
GRUENENTHAL GMBH. |
发明人 |
HELMUT BUSCHMANN;IVARS GRAUDUMS;WOLFGANG WERNER ALFRED STRASSBURGER;WERNER WINTER;PETER JANSEN;ELMAR JOSEF FRIDERICHS |
分类号 |
A61K31/135;A61P25/04;C07B57/00;C07C213/00;C07C213/08;C07C213/10;C07C215/64;C07C217/74 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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