DNA encoding granulocyte colony-stimulating factor receptor and protein thereof

摘要

PCT No. PCT/JP91/00375 Sec. 371 Date Sep. 22, 1992 Sec. 102(e) Date Sep. 22, 1992 PCT Filed Mar. 22, 1991 PCT Pub. No. WO91/14776 PCT Pub. Date Oct. 3, 1991A murine G-CSF receptor cDNA was cloned from a cDNA library prepared from mouse myeloid leukemia cells and the structure analyzed. A human G-CSF receptor cDNA was then cloned from cDNA libraries constructed from human placenta cells or human histocytic lymphoma cells using the murine G-CSF receptor cDNA as a probe, the structure analyzed and expressed in a host cell transformed with it. The stable production of human G-CSF receptor can be accomplished by transforming a host cell with the cloned G-CSF receptor cDNA and making the transformant express the G-CSF receptor.