发明名称 Tricyclic oxime ethers processes for their preparation and pharmaceutical compositions containing them
摘要 Ethers of tricyclic oximes of formula (I), their cis and trans isomers, enantiomers and diastereomers, and their hydrates and/or acid or base addn. salts, are new. R1 = H, alkyl, alkenyl, cycloalkyl, cycloalkyl(1-4C)alkyl, hydroxy, alkoxy, opt. substd. phenyl, opt. substd. phenyl(1-4C)alkyl, opt. substd. phenoxy, or opt. substd. phenyl(1-4C)alkoxy; or R1+R2 form a chain (i) such that a 5-8 atom ring is formed; R2, R3 = H, alkyl, alkenyl, cycloalkyl, opt. substd. indanyl, cycloalkyl(1-4C)alkyl, opt. substd. phenyl, or opt. substd. phenyl(1-4C)alkyl; or NR2R3 = a heterocyclic gp. (ii) or (iii); m = 0-4; n = 0, 1 or 2; Y' = O, S or N-R4; R4 = H, alkyl or opt. substd. (CH2)qphenyl; q, x, y = 0-4; A = a gp. (a), (b) or (c); R5, R6 = H, OH, alkyl, alkoxy, halo, CF3, alkoxycarbonyl, opt. substd. (CH2)p-phenyl or opt. substd. O-(CH2)p'-phenyl; p, p' = 0-4; unless otherwise stated, alkyl, alkoxy = 1-6C; alkenyl = 2-6C; cycloalkyl = 3-8C; opt. substd. = opt. substd. on phenyl by one or more alkyl, alkoxy, OH, halo, CF3, nitrile or nitro.
申请公布号 ZA9510901(B) 申请公布日期 1996.06.24
申请号 ZA19950010901 申请日期 1995.12.21
申请人 ADIR ET COMPAGNIE 发明人 SYLVAIN RAULT;MAX ROBBA;JEAN-CHARLES LANCELOT;HERVE PRUNIER;PIERRE RENARD;BRUNO PFEIFFER;BEATRICE GUARDIOLA-LEMAITRE;MARIE-CLAIRE RETTORI
分类号 A61K31/00;A61K31/40;A61K31/407;A61K31/445;A61K31/535;A61P1/00;A61P1/08;A61P1/14;A61P25/00;A61P25/04;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/26;A61P25/28;A61P25/30;A61P25/32;A61P43/00;C07D487/04;C07D495/14 主分类号 A61K31/00
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