发明名称 |
LOW TOXICITY INTERLEUKIN-2 ANALOGUES FOR USE IN IMMUNOTHERAPY. |
摘要 |
The properties of two recombinant human IL-2 analogues with mutations at Arginine 38 (->Alanine) and Phenylalanine 42 (->Lysine) were analyzed and compared to those of native IL-2. These analogues were found to maintain their ability to bind to the intermediate IL-2 receptor, p75, while binding only minimally to the high affinity p55+p75 receptor complex. The analogues also maintained the ability to stimulate peripheral blood mononuclear cells to generate lymphokine activated killing (LAK). However, IL-1 beta and TNF- alpha secretion were significantly reduced in response to the analogues, as compared to the native IL-2 molecule. These analogues are therefore potentially valuable low-toxicity alternatives to IL-2 in human immunotherapy and adoptive immunotherapy treatment strategies. |
申请公布号 |
EP0673257(A4) |
申请公布日期 |
1996.05.29 |
申请号 |
EP19930912216 |
申请日期 |
1993.04.13 |
申请人 |
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GRIMM, ELIZABETH, A.;HEATON, KEITH |
分类号 |
C12N5/10;A61K35/14;A61K38/00;A61P35/00;A61P37/04;C07K14/55 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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