A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.
申请公布号
WO9614394(A1)
申请公布日期
1996.05.17
申请号
WO1994US12922
申请日期
1994.11.08
申请人
HUMAN GENOME SCIENCES, INC.;WEI, YING-FEI;HASELTINE, WILLIAM, A.