发明名称 |
New brefeldin a derivatives and their utility in the treatment of cancer |
摘要 |
Provided are brefeldin A derivatives of the formula: <IMAGE> (II) wherein one of R1 and R2 is H and the other of R1 and R2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or a quaternary ammonium group, or a salt thereof. These derivatives exhibit good antitumor activity, and are administrable to human patients without the problems associated with brefeldin A. |
申请公布号 |
AU2905995(A) |
申请公布日期 |
1996.01.25 |
申请号 |
AU19950029059 |
申请日期 |
1995.06.29 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED B |
发明人 |
LOUIS MALSPEIS;B. RAO VISHNUVAJJALA;JEFFREY G SUPKO;CHARLES T. KANE JR. |
分类号 |
A61K31/365;A61P35/02;C07D313/00 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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