发明名称 |
A procee for preparing 3-unsubstituted cephalosporins and 1-carba(dethia) cephalosporins |
摘要 |
<p>A process for preparing 7 beta -acylamino (or 7 beta -protected amino)-3-H-1-carba(1-dethia)-3-cephem-4-carboxylic acid esters and the corresponding cephalosporins is provided. 7 beta -Acylamino (or 7 beta -protected amino)-3-halo (or 3-sulfonyl ester)-1-carba(dethia)-3-cephem carboxylic acid esters and the corresponding cephalosporins are reduced with Pd(O) and a tetra-C2-C6 alky stannane and, when a 3-sulfonyloxy ester is reduced, the process is carried out in the presence of an alkali metal halide. 3-Sulfonyloxy-3-cephem esters such as 3-mesylate, 3-tosykate and 3-triflate are employed.</p> |
申请公布号 |
IE65166(B1) |
申请公布日期 |
1995.10.04 |
申请号 |
IE19890000905 |
申请日期 |
1989.03.22 |
申请人 |
ELI LILLEY AND COMPANY |
发明人 |
COOK GWENDOLYN KAY;MCDONALD III JOHN HAMPTON |
分类号 |
C07D463/00;C07D501/04;C07D501/18;C07D501/20;C07D501/22;(IPC1-7):C07D501/20;C07D471/04 |
主分类号 |
C07D463/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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