| 摘要 |
Current commercially available fibrillar collagen compositions tend to have heterogeneous fiber size populations, including very large fibers, which are not conducive to efficient crosslinking using chemical crosslinking agents. The present invention discloses preferred methods for producing collagens having relatively homogeneous, controlled fiber size populations, which are then covalently conjugated to synthetic hydrophilic polymers, such as functionally activated polymeric glycols, to produce collagen-synthetic polymer conjugates having unique physical and chemical characteristics. The resulting conjugates are used to prepare formed implants or injectable formulations for use in a variety of therapeutic applications. Compositions of the conjugates may include additional components, such as pharmaceutically acceptable fluid carriers and/or biologically active molecules such as growth factors or cytokines.
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