6-ARYL-(METHYL- OR METHYLIDONE)-QUINOLINE DERIVATIVES AS VOLTAGE-GATED POTASSIUM CHANNEL BLOCKERS

摘要

This invention concerns a compound of generic formula (I) or a pharmaceutically acceptable salt thereof, where the dotted lines represent optional bonds, R<3> is an optionally substituted C6-C10 aryl or heteroaryl group; optionally substituted by one or more substituents the same or different, R' represents one or more optional substituents the same or different, selected from the following: halogen, C1-C6 alkyl, C2-C7 alkoxycarbonyl, C1-C6 hydroxyalkyl, CN, aminocarbonyl, C2-C7 alkanoyloxy(C1-C6)alkyl, carboxy, C2-C7 alkanoxylamino, optionally substituted C6-C10 or heteroaryl or an optionally substituted (C6-C10aryl)alkyl or a heteroaryl alkyl radical; and R" represents one or more optional mono- or di-valent substituents in the 5, 7 or 8 positions the same or different: monovalent substituents being selected from the following: C1-C6 alkyl, C2-C7 alkanoyloxy, hydroxy, amino, C2-C7 alkanoylamino, C1-C6 alkylamino, C1-C6 hydroxyalkyl, C7-C17 aralkyloxyamino, R" can also represent hydroxy in the 6 position (when the optional bond is absent); the di-valent substituents being selected from oxo (i.e. = O) and methylene (i.e. = CH2); and the N-oxides thereof, which compounds have pharmaceutical uses conferred by their ability to block voltage gated potassium channels.