Process for preparing a tetrapeptide

摘要

The tetrapeptide H-Try-Met-Asp(OH)-PheNH2 is prepared by replacing by H the protecting group X, and, if necessary, the group R, in the protected tetrapeptide X-Try-Met-Asp(OR)-PheNH2 (where X is benzyloxy-carbonyl optionally substituted in the benzene ring by one or more NO2 groups or halogen atoms, and R is H, alkyl or aralkyl) by interaction of the above protected derivative with H2 and a hydrogen atom catalyst in the presence of an organic base, followed, if necessary, by replacement by H of the group R by hydrolysis under acid (e.g. HCl or CF3COOH) or basic (e.g. NaOH) conditions.