| 发明名称 |
MONOCLONAL AND CHIMERIC ANTIBODIES SPECIFIC FOR HUMAN TUMOR NECROSIS FACTOR. |
| 摘要 |
<p>Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-a (TNFa) and are useful in vivo diagnosis and therapy of a number of TNFa-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.</p> |
| 申请公布号 |
EP0610201(A4) |
申请公布日期 |
1995.05.24 |
| 申请号 |
EP19920910625 |
申请日期 |
1992.03.18 |
| 申请人 |
UNIV NEW YORK;CENTOCOR INC |
发明人 |
LE JUNMING;VILCEK JAN;DADDONA PETER E;GHRAYEB JOHN;KNIGHT DAVID M;SIEGEL SCOTT A |
| 分类号 |
A61K39/395;A61K35/00;A61K38/00;A61P1/04;A61P1/16;A61P3/10;A61P5/14;A61P7/00;A61P9/10;A61P17/00;A61P19/02;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P37/00;A61P37/02;C07K1/22;C07K7/06;C07K7/08;C07K14/52;C07K14/525;C07K16/00;C07K16/24;C07K16/46;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/13;C12P21/02;C12P21/08;C12R1/91;G01N33/53;G01N33/577;(IPC1-7):C07K7/00;C07H15/12;C07K3/18;C07K15/28;C12N15/00 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
