New leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents

摘要

Leukotriene-B4 derivatives of formula I <IMAGE> (I) are described, in which R1 means CH2OH, CH3, CF3, COOR5, CONR6R7, or R1 together with R2 means a carbonyl group, R4 symbolizes H, C1-C10 alkyl optionally substituted, C3-C10 cycloalkyl, C6-C10 aryl radical optionally substituted, or a 5-6-membered aromatic heterocyclic ring, A symbolizes a trans, trans-CH=CH-CH=CH, a -CH2CH2-CH=CH- or a tetramethylene group, B symbolizes a C1-C10 alkylene group, which optionally can be substituted by fluorine or the group <IMAGE> D can mean a direct bond, oxygen, sulfur, -C 3BOND C-, -CH=CR6 or together with B can also mean a direct bond, their salts with physiologically compatible bases and their cyclodextrin clathrates.