TRICYCLIC SULFONAMIDE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES
摘要
A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound containing a tricyclic ring system to a biological system. In particular, the method inhibits cellular growth in a mammal such as a human being. Novel compounds of formula (4.0) are disclosed. Also disclosed are processes for making 3-substituted compounds of formula (4.0). Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of formula (4.0).
申请公布号
WO9510514(A1)
申请公布日期
1995.04.20
申请号
WO1994US11390
申请日期
1994.10.12
申请人
SCHERING CORPORATION
发明人
BISHOP, W., ROBERT;DOLL, RONALD, J.;MALLAMS, ALAN, K.;NJOROGE, F., GEORGE;PETRIN, JOANNE, M.;PIWINSKI, JOHN, J.