发明名称 |
HUMAN CELL ADHESION PROTEIN AAMP-1 AND USES THEREOF |
摘要 |
The present invention relates, in general, to AAMP-1, and to a peptide derived from the amino-terminal region of AAMP, P189. In particular, the present invention relates to a DNA segment encoding AAMP-1, P189 or fragments thereof; polypeptides encoded by said DNA segment; recombinant DNA molecules containing the DNA segment; cells containing the recombinant DNA molecule; a method of producing a AAMP-1, and P189 polypeptide or fragments thereof; antibodies specific to AAMP-1; and a method of measuring the amount of AAMP-1 in a sample. The present invention further relates to methods of using AAMP, P189 or fragments thereof in promoting cell-cell or cell-substrate adhesion, wound healing in patients, prosthetic acceptance, concentrating heparin in tissues, and inhibiting metastases and invasion of malignant cells. |
申请公布号 |
WO9500643(A3) |
申请公布日期 |
1995.03.16 |
申请号 |
WO1994US07107 |
申请日期 |
1994.06.23 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, RE |
发明人 |
BECKNER, MARIE, E.;KRUTZSCH, HENRY, C.;LIOTTA, LANCE, A. |
分类号 |
G01N33/569;A61K38/00;A61K39/395;A61P29/00;A61P35/00;A61P37/00;A61P43/00;C07H21/04;C07K7/06;C07K7/08;C07K14/16;C07K14/705;C07K14/74;C07K14/78;C07K16/00;C07K16/18;C07K16/28;C12N1/21;C12N5/10;C12N15/02;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12R1/19;G01N33/566;G01N33/577;G01N33/68 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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