| 摘要 |
<p>A solid-phase anchor carrying nucleic acids which can amplify the amount of nucleic acid probes on a solid-phase support and is satisfactorily usable in the separation and purification of DNA-binding proteins on a practical scale and in gene cloning; and a method of adjusting the anchor. The anchor contains a solid-phase support provided with an amplifier group having a number of branching ends, each of which has a binding group which can be bound to a functional group positioned at one end of a nucleic acid fragment to be bound to a predetermined nucleic acid probe. By appropriately selecting the amplifier group, it is possible to form hundreds to thousands of binding groups at one binding site of the solid-phase support and thus mount a number of nucleic acid probes.</p> |
