Functionalizing carbohydrate derivatives by base-induced beta -elimination forming bioactive derivatives containing hydroxy-diene subunits

摘要

A method to functionalize carbohydrate derivatives by base-induced beta -elimination and subsequent olefination to form biologically active products containing alpha -hydroxy-diene or alpha , beta -dihydroxy-diene subunits. Also disclosed are methods to prepare biologically active derivatives of fatty acids containing alpha -hydroxy-diene groups and alpha , beta -dihydroxy-diene groups from derivatives of 2-deoxyfuranoses and derivatives of 2-deoxypyranoses, respectively.