发明名称 |
DECORIN FRAGMENTS AND METHODS OF INHIBITING CELL REGULATORY FACTORS |
摘要 |
The present invention provides a method of inhibiting an activity of a cell regulatory factor comprising contacting the cell regulatory factor with a purified polypeptide, wherein the polypeptide comprises a cell regulatory factor binding domain of a protein. The protein is characterized by a leucine-rich repeat of about 24 amino acids. In a specific embodiment, the present invention relates to the ability of decorin, a 40,000 dalton protein that usually carries a glycosaminoglycan chain, and more specifically to active fragments of decorin or its functional equivalents to bind TGF beta . The invention also provides a cell regulatory factor designated MRF. Also provided are methods of identifying, detecting and purifying cell regulatory factors and proteins which bind and effect the activity of cell regulatory factors. |
申请公布号 |
WO9320202(A1) |
申请公布日期 |
1993.10.14 |
申请号 |
WO1993US03171 |
申请日期 |
1993.04.02 |
申请人 |
LA JOLLA CANCER RESEARCH FOUNDATION |
发明人 |
RUOSLAHTI, ERKKI, I.;PIERSCHBACHER, MICHAEL, D.;CARDENAS, JOSE;CRAIG, WILLIAM;MULLEN, DANIEL, G. |
分类号 |
C12N15/09;A61K38/00;A61K38/22;A61P43/00;C07K14/47;C07K14/495;C07K14/52;C07K14/71;C07K19/00;C12N15/12;(IPC1-7):C12N15/12;A61K37/02;C07K7/10;G01N33/53;C07K7/08;C07K7/06;C07K13/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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