| 摘要 |
The invention pertains to the synthesis and use as therapeutic agents of a group of substances with a glycerol backbone or aliphatic chain structure linked to a phosphorus atom and a polar head group. Depending on the polar head group, the substance has anti-cancer, anti-inflammatory, anti-allergy or anti-cardiovascular disease properties. Compounds of the formula: <IMAGE> wherein n is 0 to 14 and R1 is an alkyl group of C12-C20, R2 is a methyl group, and wherein R3 is an inositol analog head group, a (CH2)mN+(CH3)3 group with m=2 to 10, a serine head group, or an ethanolamine head group, or of the formula <IMAGE> wherein R1 and R2 are as described above, n=0 or 1, and R3 is (CH2)mN+(CH3)3 (m=2-10) are claimed. This invention also pertains to the synthesis and use as therapeutic agents of a group of substances that have no glycerol backbone but have an aliphatic chain structure linked directly to a phosphorus atom of the general formula R-P(O)(O-)OR' wherein R is a long-chain alkyl group such as hexadecyl or octadecyl and R' is a head group such as choline, glycerol, inositol, ethanolamine, or serine.
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