| 摘要 |
<p>Benzimidazole anthelmintic agents of the formula (I) and their non-toxic salts, wherein R1, which is in the 5(6)-position,is either H or certain stated substituents, 'alk' is a methylene or ethylene group; R2 is cyano, C¿2?-C4 alkenyl, C2-C4 alkynyl, C2-C4 alkanoyl, C1-C4 alkoxy, C2-C4 alkenoxy, aryl, heteroaryl, aryl-(C1-C4 alkoxy) or heteroaryl-(C1-C4 alkoxy), in which 'aryl' means phenyl optionally substituted by 1 to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkithio, C1-C4 alkylsulphinyl, and C1-C4 alkylsulphonyl in which 'heteroaryl' means thienyl, furyl or pyridininyl all optionally substituted by 1 to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulphinyl and C1-C4 alkylsulphonyl; and R3 is a C1-C4 alkyl group. The anthelmintic agents(I) are, unexpectedly, active topically and parenterally, and are thus suitable for spot-on, pour-on, or parental (especially intramuscular) administration.</p> |
