| 摘要 |
<p>Carbohydrate derivatives comprising a trisaccharide unit having the general formula I <CHEM> in which R is alkyl, aryl, or aralkyl; Q is alkyl, aryl, aralkyl, or SO3<->; A and B are independently selected from hydrogen, alkyl, aryl, aralkyl, or a carbohydrate group; and the charged moieties are compensated by counter-ions. The carbohydrate derivatives of this invention possess anti-thrombotic activity, and especially they have potent anti-Xa activity without activating thrombin via anti-thrombin-III (AT-III) and smooth muscle cell proliferation inhibiting activity.</p> |
