A LACTIC ACID CONDENSATE MIXTURE USEFUL AS AN INHIBITING AGENT AGAINST PROLIFERATION OF MALIGNANT TUMOR CELLS

摘要

An inhibiting agent against the proliferation of malignant tumour cells of animals including human beings comprises a mixture of an L-lactic acid straight-chain condensate having a degree of condensation of 5 to 23 and an L-lactic acid cyclic condensate having a degree of condensation of 2 to 15. The agent may be obtained by a process involving first heating lactic acid under normal pressures or reduced pressure in an atmosphere of an inert gas such as nitrogen gas. The thus obtained lactic acid low condensates are dissolved in methanol and filtered. The filtrate is dried under reduced pressure and the residue dissolved in acetonitrile. The resulting solution is passed through a reverse phase system ODS column which has previously been equilibrated by using an acidic acetonitrile solution. A fraction eluted with high concentration acetonitrile solution is collected.