| 摘要 |
A 3(2H)pyridazinone of the formula: <IMAGE> wherein R1 is C2-C5 alkyl; R2 is hydrogen, C1-C3 alkyl, chlorine or bromine; R3 is hydrogen or C1-C4 alkyl; and each of Y1, Y2 and Y3 which may be the same or different, is hydrogen, C1-C8 alkyl, C2-C8 alkenyl, halogen, -(CH2)lA [wherein A is substituted amino of the formula -N(R4) (R5) (wherein each of R4 and R5 which may be the same or different, is C1-C4 alkyl, or R4 and R5 together form C4-C6 alkylene), morpholino, 4-R6-piperazin-1-yl (wherein R6 is C1-C3 alkyl) or -OR7 (wherein R7 is hydrogen or C1-C3 alkyl), and l is an integer of 0 to 3], -OR8 [wherein R8 is hydrogen, C1-C8 alkyl, C3-C5 alkenyl, benzyl or -(CH2)q-R9 [wherein R9 is CO2R3 (wherein R3 is as defined above), -CONHR3 (wherein R3 is as defined above) or -CH2OR7 (wherein R7 is as defined above), and q is an integer of 1 to 5]], -CO2R3 (wherein R3 is as defined above), -CON(R10) (R11) [wherein each of R10 and R11 which may be the same or different, is hydrogen, C1-C4 alkyl or C3-C5 alkenyl, or R10 and R11 together form C4-C6 alkylene, -(CH2)2O(CH2)2- or -(CH2)2N(R6)(CH2)2- (wherein R6 is as defined above)], -CONH(CH2)mA (wherein A is as defined above, and m is an integer of 2 to 4), -CH=CHCOR12 (wherein R12 is hydroxy, C1-C4 alkoxy or -N(R13) (CH2)nCO2R3 (wherein R13 is hydrogen, C1-C6 alkyl or cycloalkyl, R3 is as defined above, and n is an integer of 1 to 4)), -SR14 (wherein R14 is C1-C4 alkyl), -CN or <IMAGE> wherein R3 is as defined above), or two of Y1, Y2 and Y3 together form <IMAGE> (wherein p is an integer of 1 or 2), and a pharmaceutically acceptable salt thereof.
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