| 摘要 |
Methods for treating mammals to reduce pain, reduce cell proliferation and/or reduce inflammation are described based on administering to the mammals compounds having the formula <IMAGE> wherein R1, R2, R3 and R4 are hydrogen or an acyl group having from 1 to 6 carbon atoms; R5 is hydrogen, CH3 or CH2OH and R6 is a hydrocarbon having from 1 to 10 carbon atoms. Natural and synthetic 1,12-seco derivatives with similar utilities are disclosed. Natural and synthetic derivatives are also disclosed where the sugar moiety is attached at the C-10 carbon on the tricyclic diterpene moiety instead of the C-9 carbon.
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