Dipeptide derivatives and antihypertensive drugs containing them.

摘要

There are disclosed dipeptide derivatives represented by the general formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="19" wi="66" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R' is a radical selected from the group consisting of alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R<Sup>2</Sup> is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R<Sup>3</Sup> is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R<Sup>4</Sup> is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, and R' is a radical selected from the group consisting of hydroxyl, amino, hydroxyamino, alkyloxy, aralkyloxy, aryloxy, alkylamino, aralkylamino, arylamino, alkyloxyamino, aralkyloxyamino, aryloxyamino, acylamino and sulfonylamino groups, which alkyloxy, aralkyloxy and aryloxy groups optionally containing one or more substituent groups; wherein R<Sup>3</Sup> may be combined with R<Sup>2</Sup> or R<Sup>4</Sup> to form an alkylene bridge optionally containing one or more oxygen atoms, sulfur atoms and nitrogen atoms and optionally containing one or more substituent groups. However, certain dipeptide derivatives within the above general formula are excluded from the invention. The dipeptide derivatives are useful for the treatment of hypertension.