| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is H or methoxy; Het is group of formula II (R<2> is H, alkyl, CN, etc.; R<3> is H, phenyl, etc.; R<4> is H, alkyl, etc.; X is O or S), formula III (R<6> and R<7> are H or alkyl), formula IV (n is 2-4), or formula V (R<14> is H, OH, alkyl, etc.; R<15> is acyl, alkoxycarbonyl, etc.)] and its salt. EXAMPLE:4-Amino-6,7-dimethoxy-2-(4-(5,6-dihydro-6-ethyl-5-oxop-yrido[4 ,3-d]pyri midin-2-yl)piperazino)quinazoline. USE:A hypotensor having extremely high and low-acting hypotensive effect. It little causes othostatic hypotension. PREPARATION:The compound of formula I can be prepared by reacting the compound of formula VI with the compound of formula VII in a proper solvent under refluxing, e.g. at 100-150 deg.C. |
