发明名称 |
SYNTHESIS OF VINDESINE; VINCALEUKOBLASTINE COMPOUNDS |
摘要 |
Vindesine is prepared by converting 4-desacetyl VLB C-3 carboxhydrazide to the corresponding azide with a nitrite such as n-butyl nitrite in THF and then reacting the thus formed azide with triphenylphosphine to yield an intermediate acyl iminophosphorane, which compound is decomposed with acid to yield vindesine of high purity and in good yield. |
申请公布号 |
DE3065852(D1) |
申请公布日期 |
1984.01.19 |
申请号 |
DE19803065852 |
申请日期 |
1980.01.10 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
PASCHAL, GLORIA CROSLAND;THOMPSON, GERALD LEE |
分类号 |
A61K31/475;A61P35/00;C07D519/04;C07F9/6561;(IPC1-7):C07D519/04;C07F9/50 |
主分类号 |
A61K31/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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