发明名称 |
Mitomycin C derivatives |
摘要 |
The present invention provides new derivatives of mitomycin C, represented by the formula: <IMAGE> [I] wherein R represents a hydroxy group in which case the composition is designated as 7-N-(p-hydroxyphenyl)-mitomycin C or an amino group in which case it is designated as 7-N-(p-aminophenyl)-mitomycin C. The new compounds are produced by reacting mitomycin A with p-aminophenyl or p-phenylenediamine and exhibit good antitumor and antibacterial activities.
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申请公布号 |
US4231936(A) |
申请公布日期 |
1980.11.04 |
申请号 |
US19780937376 |
申请日期 |
1978.08.28 |
申请人 |
KYOWA HAKKO KOGYO KABUSHIKI KAISHA |
发明人 |
NAKANO, KINICHI;URAKAWA, CHIKAHIRO;IMAI, RYOJI |
分类号 |
A61K31/40;A61P35/00;C07D487/14;(IPC1-7):A61K31/40;C07D487/04 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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