FREMGANGSMAADE TIL FREMSTILLING AF THIENAMYCIN OG MELLEMPRODUKTER TIL BRUG VED UDOEVELSE AF FREMGANGSMAADEN

摘要

Disclosed is a process for preparing 7-(1-hydroxethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carbox ylic acid and its pharmaceutically acceptable salts and esters (I) by total synthesis starting with L-aspartic acid and proceeding via intermediates II and IIa (4-iodomethylazetidin-2-one): I II +TR IIa