| 摘要 |
NEW MATERIAL:1,3-Dithiethane compound I [R1 is COOH, CN, benzohydryloxycarbonyl, lower alkoxycarbonyl; R2 is H, CN, COOH, NH2SO2, vinyl, NH2CO, lower alkyl, lower alkoxy, aroyl, aryl, RCO (R is lower alkoxy, etc.), etc,; R3 is H, lower alkyl]. EXAMPLE:4-[Bis(methoxycarbonyl)methylene]-1,3-dithiethane-2-carboxylic acid. USE:Intermediate of novel cephalosporin derivative useful as an antibacterial agent. PROCESS:The objective compound I can be obtained by reacting a compound II with a compound III (X is halogen). Some of the compounds II are novel. Reaction of the compound I with a compound IV (R4 is H, etc,; R5 is lower alkyl, etc.) gives a novel antibacterial compound V. The compound II is obtained by reacting R1CH2R2 with CS2. |
