NEW ENZYME AND DNA CAPABLE OF CODING THE SAME

摘要

PURPOSE:To obtain a new polypeptide useful for producing a peptide having an amidated C-terminal. CONSTITUTION:The objective polypeptide has the peptidylhydroxyglycine N-C lyase (PHL) activity and is capable of catalyzing reaction expressed the formula (R is peptide residue; GlyOH is alpha-hydroxyglycine residue connected to the C- terminal of the peptide R through amide bond). For example, AE-III. This polypeptide can be obtained by a recombinant DNA technique.