发明名称 |
composto e/ou sais farmaceuticamente aceitáveis dos mesmos, processo para síntese dos compostos, e formulação aerossol, e, uso de pelo menos uma pró-droga mútua de fenilfosfato |
摘要 |
A mutual prodrug of a corticosteroid and a substituted phenylphosphate (&bgr;-agonist derivative) for formulation for delivery by aerosolization to inhibit pulmonary inflammation and bronchoconstriction is described. The mutual prodrug is preferably formulated in a small volume solution (10-500 μL) dissolved in a quarter normal saline having pH between 5.0 and 7.0 for the treatment of respiratory tract inflammation and bronchoconstriction by an aerosol having mass median average diameter predominantly between 1 to 5μ, produced by nebulization or by dry powder inhaler. |
申请公布号 |
BRPI0611567(A2) |
申请公布日期 |
2016.11.16 |
申请号 |
BR2006PI11567 |
申请日期 |
2006.06.12 |
申请人 |
GILEAD SCIENCES INC |
发明人 |
BRUCE CHARLES GIRTON;MARCIN STASIAK;WILLIAM R. BAKER |
分类号 |
A61K31/58;C07J71/00 |
主分类号 |
A61K31/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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