The invention features a method of inhibiting tumor growth and/or tumor invasiveness in a mammal by administering to a mammal a compound (e.g., an antagonistic antibody) which inhibits expression or enzymatic activity of human aspartyl (asparaginyl) beta-hydroxylase (HAAH). The invention also features a method for diagnosing the growth of a malignant neoplasm (e.g., pancreatic cancer) in a mammal by contacting a tissue or bodily fluid from the mammal with an antibody which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and/or detecting the antigen-antibody complex.
申请公布号
WO2005016281(A2)
申请公布日期
2005.02.24
申请号
WO2004US26336
申请日期
2004.08.13
申请人
RHODE ISLAND HOSPITAL;WANDS, JACK, R.;DE LA MONTE, SUZANNE, M.;DEUTCH, ALAN, H.;GHANBARI, HOSSEIN, A.
发明人
WANDS, JACK, R.;DE LA MONTE, SUZANNE, M.;DEUTCH, ALAN, H.;GHANBARI, HOSSEIN, A.